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ANTIINFECTIVES FOR SYSTEMIC USE › VACCINES › BACTERIAL AND VIRAL VACCINES, COMBINED › Bacterial and viral vaccines, combined
diphtheria-haemophilus influenzae B-pertussis-poliomyelitis-tetanus
J07CA06
Forms & Strengths
- Injectable suspension for injection
- Single-dose vials or prefilled syringes
- Typically contains 30 IU diphtheria toxoid, 25 mcg Haemophilus influenzae type b, 4-8 mcg pertussis toxoid, 40 D-antigen units poliovirus type 1, 8 D-antigen units poliovirus type 2, 32 D-antigen units poliovirus type 3, and 20-40 IU tetanus toxoid per dose
Adult Dosing
- Not routinely recommended for adults
- May be considered for individuals with high-risk conditions or in outbreak situations
- Typical dose is 0.5 mL administered intramuscularly
Pediatric Dosing
- Primary series typically consists of 3 doses at 2, 4, and 6-7 months of age
- Booster dose recommended at 15-18 months of age
- Additional booster dose may be recommended at 4-6 years of age
- Typical dose is 0.5 mL administered intramuscularly
Indications
- Active immunization against diphtheria
- Active immunization against Haemophilus influenzae type b infection
- Active immunization against pertussis
- Active immunization against poliomyelitis
- Active immunization against tetanus
Mechanism of Action
- Stimulates the body to produce immunity against diphtheria toxin
- Induces production of antibodies against Haemophilus influenzae type b capsular polysaccharide
- Triggers an immune response against pertussis toxin and other pertussis antigens
- Stimulates production of antibodies against poliovirus types 1, 2, and 3
- Stimulates the body to produce immunity against tetanus toxin
Contraindications
- Severe allergic reaction to any component of the vaccine
- Severe allergic reaction to a previous dose of the vaccine or to any other vaccine containing similar components
- Known history of severe neurological disorders, such as encephalopathy or Guillain-Barré syndrome, within 6 weeks of a previous dose
Adverse Reactions
- Pain, redness, or swelling at the injection site
- Fever
- Fatigue
- Headache
- Nausea or vomiting
- Allergic reactions, such as hives or itching
- Seizures or other severe neurological disorders (rare)
Drug Interactions
- May interfere with the immune response to other vaccines administered simultaneously
- May be affected by immunosuppressive therapy, such as corticosteroids or chemotherapy
- Should not be administered with other vaccines containing similar components, except as authorized by a healthcare provider
Curated Content: Needs Vetting Before Put to Clinical Use