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ANTIINFECTIVES FOR SYSTEMIC USE › VACCINES › BACTERIAL AND VIRAL VACCINES, COMBINED › Bacterial and viral vaccines, combined
haemophilus influenzae B and hepatitis B
J07CA08
Forms & Strengths
- Suspension for intramuscular injection: 10 mcg Haemophilus b capsular polysaccharide conjugated to tetanus protein and 5 mcg Hepatitis B surface antigen per 0.5 mL dose
Adult Dosing
- Not routinely indicated for adults
- Special high-risk situations (e.g., asplenia, bone marrow transplant): Follow standard Hep B adult vaccination schedules if Hib co-administration is indicated
Pediatric Dosing
- Infants (6 weeks through 15 months of age): 0.5 mL intramuscularly administered as a 3-dose primary series at 2, 4, and 6 months of age
- Booster dose: 0.5 mL intramuscularly at 12 to 15 months of age
Indications
- Active immunization against invasive disease caused by Haemophilus influenzae type b
- Active immunization against infection caused by all known subtypes of hepatitis B virus
Mechanism of Action
- Induces production of anti-PRP antibodies to provide immunity against Haemophilus influenzae type b
- Induces production of anti-HBs antibodies which confer protection against hepatitis B virus infection
Contraindications
- Severe allergic reaction (e.g., anaphylaxis) after a previous dose of this vaccine, any component of the vaccine, or any other hepatitis B or Hib-containing vaccine
- Hypersensitivity to yeast or tetanus toxoid
Adverse Reactions
- Injection site reactions: pain, tenderness, erythema, swelling
- Systemic reactions: irritability, fever, drowsiness, crying, decreased appetite, vomiting
Drug Interactions
- Immunosuppressive therapies: May result in a reduced immune response to the vaccine
- Other childhood vaccines: Can be administered concomitantly with other standard pediatric vaccines at separate injection sites
Curated Content: Needs Vetting Before Put to Clinical Use