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ANTIINFECTIVES FOR SYSTEMIC USE › VACCINES › BACTERIAL AND VIRAL VACCINES, COMBINED › Bacterial and viral vaccines, combined
diphtheria-haemophilus influenzae B-pertussis-poliomyelitis-tetanus-hepatitis B
J07CA09
Forms & Strengths
- 0.5ml suspension for injection, containing: diphtheria toxoid 2-5 IU, tetanus toxoid 20-40 IU, pertussis toxoid 4-8 mcg, HBsAg 5-10 mcg, type 1 poliovirus 40 D-8 IU, type 2 poliovirus 8 IU, type 3 poliovirus 32 IU, Haemophilus influenzae type b polysaccharide 10 mcg
- various combinations and strengths available
Adult Dosing
- generally not recommended for adults, except for certain high-risk populations (e.g. those with weakened immune systems)
- consult manufacturer and clinical guidelines for specific advice
Pediatric Dosing
- primary series: 3 doses at 2, 4, and 6-7 months of age, with a booster at 15-18 months of age
- booster dose may be needed at 4-6 years of age, depending on local guidelines
- consult manufacturer and clinical guidelines for specific advice
Indications
- active immunization against diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and Haemophilus influenzae type b infections
- prevention of these diseases in infants, children, and certain high-risk populations
Mechanism of Action
- induces active immunity by stimulating production of antibodies against diphtheria toxoid, tetanus toxoid, pertussis toxoid, HBsAg, poliovirus, and Haemophilus influenzae type b polysaccharide
- protects against infection by these pathogens
Contraindications
- hypersensitivity to any component of the vaccine or to previous doses of the vaccine
- acute, severe febrile illness (vaccination may be deferred until recovery)
- pregnancy and lactation (consult clinical guidelines for specific advice)
Adverse Reactions
- common: local injection site reactions (pain, swelling, redness), fever, irritability, fretfulness
- uncommon: allergic reactions (e.g. anaphylaxis, urticaria), seizures, neurological disorders (e.g. encephalopathy, convulsions)
Drug Interactions
- may interfere with tuberculin skin tests (consult clinical guidelines for specific advice)
- concomitant administration with other vaccines may increase risk of adverse reactions
- consult manufacturer and clinical guidelines for specific advice on interactions with other medications
Curated Content: Needs Vetting Before Put to Clinical Use