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ANTIINFECTIVES FOR SYSTEMIC USE › VACCINES › BACTERIAL AND VIRAL VACCINES, COMBINED › Bacterial and viral vaccines, combined
typhoid-hepatitis A
J07CA10
Forms & Strengths
- Suspension for intramuscular injection in prefilled syringes
- Combination vaccine containing purified Vi capsular polysaccharide of Salmonella typhi (25 mcg) and inactivated Hepatitis A virus (720 ELISA units) per 1.0 mL dose
Adult Dosing
- Primary immunization: 1.0 mL given intramuscularly into the deltoid region as a single dose
- Booster vaccination: Hepatitis A component should be given 6-12 months later if prolonged protection against Hepatitis A is needed; typhoid booster recommended every 3 years if ongoing exposure risk persists
Pediatric Dosing
- Not indicated for children under 16 or 18 years of age depending on specific regional product approval (typically restricted to adults and adolescents aged 16 years and older)
Indications
- Simultaneous active immunization against typhoid fever and hepatitis A virus infection in travelers, military personnel, or endemic-risk populations aged 16 years or older
Mechanism of Action
- Induces active immunity by stimulating the production of neutralizing antibodies against Salmonella typhi Vi capsular polysaccharide and Hepatitis A virus antigens
- Confers protection against typhoid fever typically starting 2-3 weeks post-vaccination and long-term immunity against Hepatitis A
Contraindications
- History of a severe allergic reaction (e.g., anaphylaxis) to any component of the vaccine, including formaldehyde, neomycin, or the diphtheria toxoid carrier protein
- Moderate to severe acute illness with or without fever (defer vaccination until resolution)
Adverse Reactions
- Injection site reactions: pain, redness, swelling, and induration
- Systemic reactions: headache, fatigue, malaise, low-grade fever, and nausea
Drug Interactions
- Immunosuppressive therapies (including high-dose corticosteroids and chemotherapy): may reduce the immune response to the vaccine
- Other inactivated vaccines: can generally be administered concomitantly at different injection sites
Curated Content: Needs Vetting Before Put to Clinical Use