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diphtheria-haemophilus influenzae B-pertussis-tetanus-hepatitis B

J07CA11

Forms & Strengths

Injection: diphtheria toxoid 10-20 Lf, haemophilus influenzae type b 10-20 mcg, pertussis toxoid 2-5 Lf, tetanus toxoid 5-10 Lf, hepatitis B surface antigen 5-20 mcg per 0.5 mL
Single-dose vials or syringes
Preservative-free

Adult Dosing

Not recommended for adults, only for children under 7 years
Catch-up vaccination for adults not vaccinated in childhood: 1 dose of Td or Tdap

Pediatric Dosing

Primary series: 3 doses at 2, 4, and 6-12 months of age
Booster dose: 1 dose at 12-18 months of age
Catch-up vaccination for children 7 years and older: 1 dose of Tdap

Indications

Active immunization against diphtheria, haemophilus influenzae type b, pertussis, tetanus, and hepatitis B infections
Prevention of diseases caused by these microorganisms in infants and children under 7 years

Mechanism of Action

Stimulates the production of antibodies against diphtheria, haemophilus influenzae type b, pertussis, tetanus, and hepatitis B
Provides immunity against these diseases by inducing a cell-mediated immune response

Contraindications

Hypersensitivity to any component of the vaccine or previous dose
Severe allergic reaction to a previous dose of any vaccine containing diphtheria, haemophilus influenzae type b, pertussis, tetanus, or hepatitis B
Encephalopathy within 7 days of a previous dose of a pertussis-containing vaccine

Adverse Reactions

Local reactions: pain, redness, swelling, and induration at the injection site
Systemic reactions: fever, irritability, crying, and vomiting
Allergic reactions: anaphylaxis, pruritus, and urticaria

Drug Interactions

Immunosuppressive therapy: may decrease the immune response to the vaccine
Other vaccines: may be administered concomitantly, but at a different injection site

Curated Content: Needs Vetting Before Put to Clinical Use