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ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ANTINEOPLASTIC AGENTS › ALKYLATING AGENTS › Nitrogen mustard analogues
chlormethine
L01AA05
Forms & Strengths
- 10 mg/mL solution for injection
Adult Dosing
- 0.4 mg/kg IV on days 1 and 15 of 28-day cycle
- Topical application: 0.4% solution for skin lesions
Pediatric Dosing
- Safety and efficacy not established
Indications
- Cutaneous T-cell lymphoma
- Hodgkin lymphoma
- Lymphosarcoma
- Mycois fungoides
Mechanism of Action
- Alkylating agent
- Forms cross-links in DNA strands
- Interferes with DNA replication and transcription
Contraindications
- Hypersensitivity to chlormethine
- Active infection
Adverse Reactions
- Bone marrow suppression
- Neutropenia
- Thrombocytopenia
- Nausea and vomiting
- Alopecia
- Skin lesions
Drug Interactions
- Concomitant immunosuppressants increase risk of infection
- Myelosuppression when co-administered with other alkylating agents
Curated Content: Needs Vetting Before Put to Clinical Use