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ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ENDOCRINE THERAPY › HORMONES AND RELATED AGENTS › Progestogens
gestonorone
L02AB03
Forms & Strengths
- injectable suspension 40 mg/mL
- implant 40-60 mg
Adult Dosing
- 104 mg every 12 weeks
- injection: administer intramuscularly
- implant: administer subdermally in abdominal wall
Pediatric Dosing
- not recommended for use in pediatric patients
Indications
- treatment of endometriosis
- treatment of uterine fibroids
- contraception
Mechanism of Action
- binds to progesterone receptors
- inhibits ovulation
- alters endometrial and myometrial growth
Contraindications
- pregnancy
- breast cancer
- liver disease
- undidiagnosed vaginal bleeding
Adverse Reactions
- weight gain
- acne
- headache
- breast tenderness
- mood changes
Drug Interactions
- may interact with CYP3A4 inhibitors or inducers
- may interact with other hormonal therapies
Curated Content: Needs Vetting Before Put to Clinical Use