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ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ENDOCRINE THERAPY › HORMONE ANTAGONISTS AND RELATED AGENTS › Anti-estrogens
tamoxifen
L02BA01
Forms & Strengths
- 10mg, 20mg tablets
- 10mg, 20mg oral solution
Adult Dosing
- 20-40mg/day for breast cancer treatment
- 20mg/day for breast cancer prevention
- 40mg/day for advanced or metastatic disease
Pediatric Dosing
- Not established for use in pediatric patients
- Use with caution in adolescents with McCune-Albright Syndrome
Indications
- Treatment of breast cancer
- Reduction of breast cancer risk in high-risk women
- Treatment of ductal carcinoma in situ
- Treatment of McCune-Albright Syndrome
Mechanism of Action
- Selective estrogen receptor modulator (SERM)
- Competes with estrogen for binding to estrogen receptors
- Inhibits estrogen-induced growth in breast tissue
Contraindications
- Hypersensitivity to tamoxifen
- Pregnancy and lactation
- Women with a history of deep vein thrombosis or pulmonary embolism
Adverse Reactions
- Hot flashes
- Vaginal discharge
- Nausea and vomiting
- Thromboembolic events
- Endometrial cancer
Drug Interactions
- CYP2D6 inhibitors (e.g. SSRI antidepressants) reduce tamoxifen efficacy
- Concomitant use with warfarin increases risk of bleeding
- Avoid concomitant use with other estrogen-containing products
Curated Content: Needs Vetting Before Put to Clinical Use