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ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ENDOCRINE THERAPY › HORMONE ANTAGONISTS AND RELATED AGENTS › Anti-androgens
nilutamide
L02BB02
Forms & Strengths
- Tablets: 50 mg, 150 mg
- Oral use
Adult Dosing
- 150 mg daily, for 30 days after surgical castration, then 50 mg daily
- Dose adjustment for hepatic impairment may be necessary
Pediatric Dosing
- Not indicated for use in pediatric patients
- Safety and efficacy not established
Indications
- Treatment of metastatic prostatic cancer, in combination with surgical castration
- Hormone-sensitive metastatic prostate cancer
Mechanism of Action
- Non-steroidal anti-androgen, blocks androgen receptors
- Inhibits androgen effects on prostate cancer cells
Contraindications
- Hypersensitivity to nilutamide or other anti-androgens
- Severe hepatic impairment, severe respiratory insufficiency
Adverse Reactions
- Hot flashes, sweating, impotence, decreased libido
- Gynecomastia, breast pain, diarrhea, nausea, fatigue
Drug Interactions
- Increased risk of liver toxicity with concomitant theophylline use
- Monitor warfarin levels when co-administered, potential for increased anticoagulation
Curated Content: Needs Vetting Before Put to Clinical Use