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ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › IMMUNOSTIMULANTS › IMMUNOSTIMULANTS › Colony stimulating factors
ancestim
L03AA12
Forms & Strengths
- Solution for injection: 5mg/mL
- Single-use prefilled syringe: 5mg/0.5mL
Adult Dosing
- Typical dose: 5mg once daily
- Subcutaneous injection
- Dose adjustment in renal impairment: not required
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Use not recommended under 18 years of age
Indications
- Stimulation of hematopoiesis in cancer patients
- Reducing the incidence of febrile neutropenia
- Increasing white blood cell counts during chemotherapy
Mechanism of Action
- Recombinant granulocyte colony-stimulating factor (G-CSF)
- Stimulates production of neutrophils
- Decreases risk of febrile neutropenia and infections
Contraindications
- Hypersensitivity to filgrastim or E. coli-derived proteins
- Sickle cell crisis
Adverse Reactions
- Bone pain
- Headache
- Fatigue
- Nausea
- Muscle pain
- Fever
- Injection site reactions
Drug Interactions
- Decreased cytotoxic effects of chemotherapy when used concurrently
- Interference with diagnostic blood tests measuring WBC counts
Curated Content: Needs Vetting Before Put to Clinical Use