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ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › IMMUNOSTIMULANTS › IMMUNOSTIMULANTS › Interferons
interferon alfacon-1
L03AB09
Forms & Strengths
- solution for injection 30 mcg/mL
Adult Dosing
- 9 mcg TIW for chronic hepatitis C
- 15 mcg TIW for other conditions
- Dose adjustments based on tolerance and efficacy
Pediatric Dosing
- Not established for pediatric patients
- Use with caution, monitor for adverse reactions
Indications
- Chronic hepatitis C
- Chronic hepatitis B
- Hairy cell leukemia
- AIDS-related Kaposi’s sarcoma
- Follicular lymphoma
Mechanism of Action
- Stimulates immune response
- Induces production of antiviral proteins
- Inhibits viral replication
- Modulates cell proliferation
Contraindications
- Hypersensitivity to interferon
- Autoimmune hepatitis
- Severe psychiatric disorders
Adverse Reactions
- Flu-like symptoms
- Fatigue
- Anemia
- Neutropenia
- Thrombocytopenia
- Depression
- Psychosis
Drug Interactions
- Theophylline: increased risk of theophylline toxicity
- Zidovudine: increased risk of neutropenia
- Telbivudine: increased risk of peripheral neuropathy
Curated Content: Needs Vetting Before Put to Clinical Use