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ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › IMMUNOSTIMULANTS › IMMUNOSTIMULANTS › Other immunostimulants
poly I:C
L03AX07
Forms & Strengths
- Injectable solution
- Lyophilized powder for injection
Adult Dosing
- 1.5-6 mg/m² IV or IM once daily
- Dosage may vary depending on specific disease and institutional protocols
Pediatric Dosing
- Not established
- Limited data available for pediatric use
Indications
- Adjuvant therapy for chronic hepatitis B and C
- Cancer immunotherapy
- Antiviral therapy
Mechanism of Action
- Stimulates interferon production
- Induces production of cytokines
- Activates natural killer cells and macrophages
Contraindications
- Hypersensitivity to poly I:C
- Autoimmune disorders
- Severe renal or hepatic impairment
Adverse Reactions
- Flu-like symptoms
- Fatigue
- Myalgia
- Chills
- Fever
Drug Interactions
- Interferons and other immunomodulators
- Live vaccines
- Immunosuppressants
Curated Content: Needs Vetting Before Put to Clinical Use