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ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › IMMUNOSTIMULANTS › IMMUNOSTIMULANTS › Other immunostimulants
glatiramer acetate
L03AX13
Forms & Strengths
- 20mg/mL prefilled syringe
- 40mg/mL prefilled syringe
Adult Dosing
- 20mg subcutaneously three times a week
- 40mg subcutaneously three times a week (after initiation with 20mg)
Pediatric Dosing
- Safety and efficacy not established in patients under 18 years of age
Indications
- Treatment of relapsing-remitting multiple sclerosis
- To delay the onset of clinically definite multiple sclerosis
Mechanism of Action
- Modulates immune system by altering T-cell activation and proliferation
- Reduces pro-inflammatory cytokines and increases anti-inflammatory cytokines
Contraindications
- Hypersensitivity to glatiramer acetate or mannitol
- Severe hypersensitivity reactions, including anaphylaxis
Adverse Reactions
- Injection site reactions
- Lymphadenopathy
- Asthenia
- Pain
- Chest pain
- Post-injection reaction syndrome
Drug Interactions
- Concomitant use with other immunomodulatory therapies not recommended
- Caution when co-administering with other drugs that have immunomodulatory effects
Curated Content: Needs Vetting Before Put to Clinical Use