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ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › IMMUNOSUPPRESSANTS › IMMUNOSUPPRESSANTS › Monoclonal antibodies
emapalumab
L04AG09
Forms & Strengths
- Single-dose vials of 100 mg/10 mL, 200 mg/20 mL
Adult Dosing
- Recommended dosage for adult and pediatric patients is 10 mg/kg
Pediatric Dosing
- Use same dosing as adults, with adjustments for weight, in Primary Hemophagocytic Lymphohistiocytosis (HLH)
Indications
- Treatment of Primary Hemophagocytic Lymphohistiocytosis (HLH)
Mechanism of Action
- Interferon gamma (IFN-γ) neutralizing monoclonal antibody
Contraindications
- Live vaccines, Concurrent use with certain immunosuppressive therapies
Adverse Reactions
- Infections, Infusion-related reactions, Hypersensitivity reactions
Drug Interactions
- Live vaccines, Immunomodulatory or immunosuppressive drugs
Curated Content: Needs Vetting Before Put to Clinical Use