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oxyphenbutazone

M01AA03

Forms & Strengths

Oral tablets: 100 mg

Adult Dosing

Rheumatoid arthritis, osteoarthritis, acute gout: 100 mg to 200 mg orally 3 to 4 times daily
Maximum daily dose: 600 mg
Use lowest effective dose for the shortest possible duration due to toxicity risks

Pediatric Dosing

Safety and efficacy not established in pediatric patients; generally contraindicated

Indications

Short-term treatment of severe acute inflammatory conditions of the musculoskeletal system
Acute gouty arthritis
Rheumatoid arthritis and osteoarthritis flare-ups (historical usage due to high toxicity)

Mechanism of Action

Non-steroidal anti-inflammatory drug (NSAID) and pyrazolone derivative
Inhibits cyclooxygenase (COX), leading to decreased prostaglandin synthesis
Possesses anti-inflammatory, analgesic, and antipyretic properties

Contraindications

Known hypersensitivity to oxyphenbutazone, phenylbutazone, or other NSAIDs
History of peptic ulcer disease or active gastrointestinal bleeding
Severe hepatic, renal, or cardiac dysfunction
History of blood dyscrasias or bone marrow depression
Children under 14 years of age

Adverse Reactions

Agranulocytosis, aplastic anemia, leukopenia, thrombocytopenia
Peptic ulceration, gastrointestinal bleeding, perforation, nausea, dyspepsia
Fluid retention, edema, hypertension, congestive heart failure
Hepatotoxicity, elevated liver enzymes
Skin rashes, Stevens-Johnson syndrome, toxic epidermal necrolysis

Drug Interactions

Oral anticoagulants (e.g., warfarin): enhanced bleeding risk and displacement from plasma proteins
Oral hypoglycemic agents (e.g., sulfonylureas): enhanced hypoglycemic effect
Lithium: decreased renal clearance leading to increased lithium toxicity
Methotrexate: increased hematologic toxicity due to reduced clearance
Other ulcerogenic drugs (e.g., corticosteroids): increased risk of severe gastrointestinal adverse effects

Curated Content: Needs Vetting Before Put to Clinical Use