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MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Acetic acid derivatives and related substances
aceclofenac
M01AB16
Forms & Strengths
- Tablets: 100mg
- Tablets: 200mg
- Gel: 1.5% w/w
- Suppositories: 100mg
- Suppositories: 200mg
- Emulgel: 1.5% w/w
Adult Dosing
- 100mg to 200mg orally daily
- Dose can be divided into 1 or 2 intakes
- Maximum dose: 200mg daily
- Treatment duration: as needed
Pediatric Dosing
- Not recommended under 18 years of age
- Use in children and adolescents: not established
Indications
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Low back pain
- Dental pain
Mechanism of Action
- Non-selective COX inhibitor
- Inhibits prostaglandin synthesis
- Reduces inflammation and pain
Contraindications
- Hypersensitivity to aceclofenac
- Active peptic ulcer
- Severe heart failure
- Chronic kidney disease stage 4 or worse
- Severe liver dysfunction
Adverse Reactions
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Peptic ulcer
- Gastrointestinal bleeding
- Hypertension
- Edema
Drug Interactions
- Aspirin: increased risk of GI bleeding
- Warfarin: increased risk of bleeding
- Diuretics: reduced diuretic effect
- Beta blockers: reduced antihypertensive effect
- Lithium: increased lithium levels
Curated Content: Needs Vetting Before Put to Clinical Use