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MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Oxicams
tenoxicam
M01AC02
Forms & Strengths
- Tablet 20 mg
- Suppository 20 mg
- Lyophilized powder for injection 20 mg
Adult Dosing
- Osteoarthritis: 20 mg once daily orally or IV/IM
- Rheumatoid arthritis: 20 mg once daily orally or IV/IM
- Acute musculoskeletal disorders and gout: 20 mg once daily for up to 7 days
Pediatric Dosing
- Not recommended for use in children and adolescents under 18 years of age due to lack of safety and efficacy data
Indications
- Symptomatic treatment of osteoarthritis
- Symptomatic treatment of rheumatoid arthritis
- Management of ankylosing spondylitis
- Short-term treatment of acute musculoskeletal disorders and acute gout
Mechanism of Action
- Non-steroidal anti-inflammatory drug (NSAID) of the oxicam class
- Inhibits cyclooxygenase (COX-1 and COX-2) enzymes
- Reduces synthesis of pro-inflammatory prostaglandins from arachidonic acid
- Possesses analgesic, anti-inflammatory, and antipyretic properties
Contraindications
- Hypersensitivity to tenoxicam or other NSAIDs (history of asthma, rhinitis, or urticaria)
- Active peptic ulcer disease or history of recurrent gastrointestinal ulceration/hemorrhage
- Severe heart failure
- Severe hepatic impairment
- Severe renal impairment (CrCl < 30 mL/min)
- Third trimester of pregnancy
Adverse Reactions
- Gastrointestinal: dyspepsia, nausea, abdominal pain, diarrhea, GI ulceration, bleeding
- Central nervous system: headache, dizziness, drowsiness
- Skin: rash, pruritus, bullous reactions, Stevens-Johnson syndrome (rare)
- Renal: fluid retention, edema, elevated serum creatinine, renal failure
- Cardiovascular: hypertension, increased risk of thrombotic events
Drug Interactions
- Anticoagulants (e.g., warfarin): increased risk of severe bleeding
- Antiplatelet agents and SSRIs: increased risk of gastrointestinal bleeding
- Diuretics, ACE inhibitors, and ARBs: decreased antihypertensive efficacy and increased risk of nephrotoxicity
- Lithium and methotrexate: decreased renal clearance, leading to increased toxicity
- Other NSAIDs and corticosteroids: increased risk of gastrointestinal adverse effects
Curated Content: Needs Vetting Before Put to Clinical Use