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MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Propionic acid derivatives
fenoprofen
M01AE04
Forms & Strengths
- Tablets: 200mg, 300mg, 400mg, 600mg
- Capsules: 200mg, 300mg, 400mg
- Oral suspension
Adult Dosing
- Osteoarthritis: 300-600mg tid/qid
- Rheumatoid arthritis: 300-600mg tid/qid
- Pain relief: 200-400mg q4-6h
Pediatric Dosing
- Not recommended for children under 12 years
- 12-18 years: 200-300mg tid/qid, use with caution
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Pain relief
Mechanism of Action
- Inhibits prostaglandin synthesis
- Blocks cyclooxygenase (COX) enzymes
- Reduces inflammation and pain
Contraindications
- Hypersensitivity to fenoprofen or NSAIDs
- Active peptic ulcer
- Severe renal impairment
- Pregnancy (third trimester)
Adverse Reactions
- Gastrointestinal upset
- Nausea and vomiting
- Diarrhea or constipation
- Headache
- Dizziness
- Allergic reactions
Drug Interactions
- Increases lithium toxicity
- Enhances anticoagulant effects
- Concomitant use with aspirin increases GI risk
- Decreases diuretic effectiveness
Curated Content: Needs Vetting Before Put to Clinical Use