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indoprofen

M01AE10

Forms & Strengths

Oral capsules 100 mg
Oral tablets 200 mg
Injectable solution 100 mg/2 mL

Adult Dosing

Rheumatoid arthritis and osteoarthritis: 200 mg to 400 mg daily in divided doses
Acute pain and dysmenorrhea: 100 mg to 200 mg every 6 to 8 hours as needed
Maximum daily dose generally not to exceed 600 mg

Pediatric Dosing

Safety and efficacy in pediatric patients have not been established
Use in children is generally not recommended

Indications

Management of inflammatory conditions such as rheumatoid arthritis and osteoarthritis
Relief of mild to moderate acute pain
Treatment of primary dysmenorrhea

Mechanism of Action

Nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX-1 and COX-2) enzymes
Reduces synthesis of pro-inflammatory prostaglandins from arachidonic acid
Possesses analgesic, anti-inflammatory, and antipyretic properties

Contraindications

Hypersensitivity to indoprofen or history of aspirin/NSAID-induced asthma or urticaria
Active peptic ulcer disease or gastrointestinal bleeding
Severe heart failure, hepatic impairment, or renal impairment
Third trimester of pregnancy

Adverse Reactions

Gastrointestinal: dyspepsia, nausea, abdominal pain, peptic ulceration, GI bleeding
Central nervous system: headache, dizziness, drowsiness
Dermatological: rash, pruritus
Renal: fluid retention, edema, elevated serum creatinine, decreased renal function
Hematological: prolonged bleeding time, anemia

Drug Interactions

Anticoagulants (e.g., warfarin): increased risk of severe bleeding
Antihypertensives and diuretics: diminished antihypertensive and diuretic efficacy; increased risk of nephrotoxicity
Lithium and methotrexate: reduced renal clearance leading to potential toxicity
Other NSAIDs or corticosteroids: additive gastrointestinal toxicity and ulceration risk

Curated Content: Needs Vetting Before Put to Clinical Use