← Search & browse all drugs
MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Fenamates
flufenamic acid
M01AG03
Forms & Strengths
- Capsules: 50mg, 100mg
- Tablets: 50mg, 100mg, 200mg
- Oral suspension: 25mg/5mL
Adult Dosing
- Osteoarthritis: 100-200mg twice daily
- Rheumatoid arthritis: 100-200mg 3-4 times daily
- Ankylosing spondylitis: 100-200mg twice daily
- Pain relief: 50-100mg every 6-8 hours as needed
Pediatric Dosing
- Not recommended for children under 12 years
- Juvenile rheumatoid arthritis (12 years and older): 50-100mg 3-4 times daily
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Pain relief
- Dysmenorrhea
- Menstrual cramps
Mechanism of Action
- Inhibits cyclooxygenase (COX-1 and COX-2) enzymes
- Blocks prostaglandin synthesis
- Exerts anti-inflammatory, analgesic, and antipyretic effects
Contraindications
- Known hypersensitivity to flufenamic acid
- Active peptic ulcer disease
- Severe renal impairment
- Severe hepatic impairment
- Pregnancy and lactation
Adverse Reactions
- Gastrointestinal upset
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Headache
- Dizziness
- Rash
- Hypersensitivity reactions
Drug Interactions
- Aspirin: increased risk of gastrointestinal toxicity
- Warfarin: increased risk of bleeding
- Lithium: increased lithium levels
- Methotrexate: increased methotrexate toxicity
- Cyclosporine: increased cyclosporine levels
Curated Content: Needs Vetting Before Put to Clinical Use