← Search & browse all drugs
MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Coxibs
celecoxib
M01AH01
Forms & Strengths
- Capsules: 50mg, 100mg, 200mg, 400mg
- Tablets: 100mg, 200mg
- Oral suspension: 50mg/5mL
Adult Dosing
- Osteoarthritis: 100-200mg/day
- Rheumatoid arthritis: 100-200mg twice daily
- Ankylosing spondylitis: 100-200mg twice daily
- Acute pain: 400mg initially, then 200mg as needed
- Primary dysmenorrhea: 400mg initially, then 200mg as needed
Pediatric Dosing
- Juvenile rheumatoid arthritis (JRA): 2mg/kg/dose twice daily
- Limited data for use in children under 2 years
Indications
- Osteoarthritis (OA)
- Rheumatoid arthritis (RA)
- Ankylosing spondylitis (AS)
- Acute pain
- Primary dysmenorrhea
- Juvenile rheumatoid arthritis (JRA)
Mechanism of Action
- Selective cyclooxygenase-2 (COX-2) inhibitor
- Inhibits prostaglandin synthesis
- Reduces inflammation and pain
Contraindications
- Known hypersensitivity to celecoxib
- Active gastrointestinal bleeding
- Recent myocardial infarction or stroke
- Severe heart failure
- Sulfonamide allergy
Adverse Reactions
- Gastrointestinal: abdominal pain, diarrhea, dyspepsia
- Cardiovascular: hypertension, edema
- Central nervous system: headache, dizziness
- Dermatologic: rash, pruritus
- Hepatic: elevated liver enzymes
Drug Interactions
- Aspirin: increased risk of gastrointestinal toxicity
- Warfarin: increased risk of bleeding
- Lithium: increased lithium levels
- Ace inhibitors and angiotensin II receptor blockers: increased risk of hyperkalemia
- Fluconazole: increased celecoxib levels
Curated Content: Needs Vetting Before Put to Clinical Use