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MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Other antiinflammatory and antirheumatic agents, non-steroids
feprazone
M01AX18
Forms & Strengths
- Tablets: 100mg, 200mg
- Injectable solution: 100mg/2mL, 200mg/4mL
- Suppositories: 100mg, 200mg
Adult Dosing
- Osteoarthritis: 200-400mg/day, divided into 2-3 doses
- Rheumatoid arthritis: 200-400mg/day, divided into 2-3 doses
- Acute pain: 200mg as a single dose, then 200mg every 4-6 hours as needed
Pediatric Dosing
- Not recommended for children under 15 years old
- For children over 15 years old, follow adult dosing
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Acute musculoskeletal pain
- Dysmenorrhea
Mechanism of Action
- Non-selective inhibition of cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis
- Anti-inflammatory, analgesic, and antipyretic effects
Contraindications
- Known hypersensitivity to feprazone or other NSAIDs
- Active peptic ulcer disease
- Severe heart failure
- Severe renal impairment
- Third trimester of pregnancy
Adverse Reactions
- Gastrointestinal: nausea, vomiting, diarrhea, abdominal pain
- Cardiovascular: hypertension, edema, increased risk of heart attack or stroke
- Renal: increased serum creatinine, renal failure
- Hematologic: anemia, thrombocytopenia
Drug Interactions
- Increased risk of bleeding with anticoagulants, antiplatelets, and SSRIs
- Decreased diuretic efficacy with loop and thiazide diuretics
- Increased risk of nephrotoxicity with ACE inhibitors and angiotensin II receptor blockers
Curated Content: Needs Vetting Before Put to Clinical Use