← Search & browse all drugs

feprazone, combinations

M01AX68

Forms & Strengths

Combination oral capsules containing feprazone and analgesics/muscle relaxants
Various regional fixed-dose combination tablets

Adult Dosing

1 capsule or tablet orally 2 to 3 times daily after meals
Short-term use recommended due to adverse effect profile

Pediatric Dosing

Safety and efficacy not established in pediatric patients
Not recommended for use in children

Indications

Short-term management of acute painful musculoskeletal and joint disorders
Inflammatory conditions associated with muscle spasm

Mechanism of Action

Feprazone acts as a non-steroidal anti-inflammatory drug (NSAID) inhibiting prostaglandin synthesis via cyclooxygenase (COX) inhibition
Combination components may provide concurrent skeletal muscle relaxation or central analgesia

Contraindications

Hypersensitivity to feprazone, phenylbutazone derivatives, or other NSAIDs
Active peptic ulcer disease or history of gastrointestinal bleeding
Severe hepatic, renal, or cardiac impairment
History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs

Adverse Reactions

Gastrointestinal distress, nausea, dyspepsia, and peptic ulceration
Central nervous system effects including dizziness, drowsiness, and headache
Hypersensitivity skin reactions, rash, and pruritus
Hematological abnormalities with prolonged use, including leukopenia or agranulocytosis

Drug Interactions

Increased risk of gastrointestinal ulceration and bleeding with concurrent anticoagulants or other NSAIDs
May enhance the hypoglycemic effects of sulfonylureas and the toxicity of methotrexate
Potential decrease in the efficacy of antihypertensive agents and diuretics

Curated Content: Needs Vetting Before Put to Clinical Use