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aurotioprol

M01CB05

Forms & Strengths

Auranofin 0.1% oral solution
Gold sodium thiomalate 50mg/mL injection

Adult Dosing

6-9mg/day oral in divided doses
10-25mg IM/IV once weekly

Pediatric Dosing

0.15-0.2mg/kg/day oral

Indications

Rheumatoid arthritis
Psoriatic arthritis

Mechanism of Action

Inhibits mononuclear phagocytic system function
Reduces T-cell mediated inflammation
Decreases interleukin-1 (IL-1) production

Contraindications

Pregnancy
Nursing mothers
Gold allergy
Severe bone marrow depression

Adverse Reactions

Mucocutaneous reactions (rash, stomatitis, diarrhea)
Proteinuria
Hematologic disorders (leukopenia, thrombocytopenia)
Gastrointestinal upset

Drug Interactions

Penicillamine (increased risk of renal toxicity)
Phenytoin (decreased serum phenytoin)
Live vaccines (avoid use)

Curated Content: Needs Vetting Before Put to Clinical Use