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MUSCULO-SKELETAL SYSTEM › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › Antiinflammatory preparations, non-steroids for topical use
mofebutazone
M02AA02
Forms & Strengths
- Tablets: 150mg, 200mg, 250mg, 300mg
- Capsules: 200mg
- Injectable solution: 100mg/mL
Adult Dosing
- Osteoarthritis: 200-300mg orally 2-3 times a day
- Rheumatoid arthritis: 200-400mg orally 2-3 times a day
- Acute musculoskeletal pain: 200-400mg orally 2-3 times a day
Pediatric Dosing
- Not recommended for children under 12 years old
- For children over 12 years old, use adult dosing with caution
Indications
- Treatment of osteoarthritis
- Treatment of rheumatoid arthritis
- Treatment of ankylosing spondylitis
- Relief of acute musculoskeletal pain
Mechanism of Action
- Inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes
- Exhibits anti-inflammatory, analgesic, and antipyretic properties
Contraindications
- Hypersensitivity to mofebutazone or other nonsteroidal anti-inflammatory drugs (NSAIDs)
- Active peptic ulcer disease
- Severe liver or kidney dysfunction
Adverse Reactions
- Gastrointestinal: nausea, vomiting, diarrhea, abdominal pain
- Hepatic: elevated liver enzymes, hepatitis
- Renal: renal impairment, acute kidney injury
- Hematologic: anemia, thrombocytopenia
Drug Interactions
- Increases risk of bleeding with anticoagulants and antiplatelets
- Enhances hypoglycemic effects of oral antidiabetics
- Reduces diuretic and antihypertensive effects of diuretics and beta blockers
Curated Content: Needs Vetting Before Put to Clinical Use