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MUSCULO-SKELETAL SYSTEM › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › Antiinflammatory preparations, non-steroids for topical use
etofenamate
M02AA06
Adult Dosing
- apply 2-4g to affected area 2-4 times daily
- maximum daily dose 16g
Pediatric Dosing
- not recommended for children under 12 years
- limited data available for children over 12 years
Indications
- relief of localized pain and inflammation in osteoarthritis
- relief of localized pain and inflammation in rheumatoid arthritis
- relief of localized pain and inflammation in sprains and strains
Mechanism of Action
- non-selective COX inhibitor
- inhibits prostaglandin synthesis
Contraindications
- hypersensitivity to etofenamate
- peptic ulcer disease
- severe renal impairment
- severe hepatic impairment
Adverse Reactions
- skin irritation
- contact dermatitis
- pruritus
- burning sensation
Drug Interactions
- increased risk of bleeding with warfarin
- increased risk of nephrotoxicity with aminoglycosides
- increased risk of lithium toxicity
Curated Content: Needs Vetting Before Put to Clinical Use