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MUSCULO-SKELETAL SYSTEM › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › Antiinflammatory preparations, non-steroids for topical use
piroxicam
M02AA07
Forms & Strengths
- Capsule: 10 mg
- Capsule: 20 mg
Adult Dosing
- Osteoarthritis: 20 mg orally once daily
- Rheumatoid arthritis: 20 mg orally once daily
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Management of acute or chronic osteoarthritis
- Management of acute or chronic rheumatoid arthritis
Mechanism of Action
- Nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX-1 and COX-2)
- Decreases synthesis of pro-inflammatory prostaglandins, reducing pain and inflammation
Contraindications
- Known hypersensitivity to piroxicam
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
- Active peptic ulcer disease or gastrointestinal bleeding
Adverse Reactions
- Gastrointestinal ulceration, bleeding, and perforation
- Hypertension and edema
- Renal toxicity including renal papillary necrosis and acute renal failure
- Serious skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis
- Increased risk of thrombotic cardiovascular events
Drug Interactions
- Anticoagulants (e.g., warfarin): Increased risk of severe bleeding
- Antiplatelet agents (e.g., aspirin): Increased risk of GI ulceration and bleeding
- ACE inhibitors and ARBs: Diminished antihypertensive effect and increased risk of renal impairment
- Diuretics: Reduced efficacy and increased nephrotoxicity risk
- Lithium: Decreased renal clearance leading to elevated plasma lithium levels
Curated Content: Needs Vetting Before Put to Clinical Use