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MUSCULO-SKELETAL SYSTEM › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › Antiinflammatory preparations, non-steroids for topical use
bufexamac
M02AA09
Forms & Strengths
- Topical cream 5%
- Topical ointment 5%
Adult Dosing
- Apply a thin layer to the affected area 2 to 3 times daily
- Limit prolonged use on large skin areas
Pediatric Dosing
- Safety and efficacy in pediatric patients not well established
- Use with caution in children if prescribed, avoiding extensive application
Indications
- Inflammatory skin conditions such as eczema and dermatitis
- Pruritus and minor allergic skin reactions
Mechanism of Action
- Non-steroidal anti-inflammatory drug (NSAID) applied topically
- Inhibits prostaglandin synthesis via cyclooxygenase (COX) inhibition to reduce inflammation and pain
Contraindications
- Hypersensitivity to bufexamac or other NSAIDs
- Tuberculous or syphilitic skin lesions
- Viral skin infections (e.g., varicella, herpes simplex)
- Open wounds and broken skin
Adverse Reactions
- Contact dermatitis and allergic skin reactions
- Erythema, burning, and pruritus at application site
- Photosensitivity
Drug Interactions
- Minimal systemic absorption, but concurrent use of other topical agents on the same site may alter absorption
- Potential additive sensitization with other contact allergens
Curated Content: Needs Vetting Before Put to Clinical Use