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MUSCULO-SKELETAL SYSTEM › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › Antiinflammatory preparations, non-steroids for topical use
ibuprofen
M02AA13
Forms & Strengths
- Tablets: 200mg, 400mg, 600mg, 800mg
- Capsules: 200mg, 400mg
- Oral suspension: 100mg/5mL
- Injected solutions: 400mg/4mL, 800mg/8mL
Adult Dosing
- Pain relief: 200-400mg every 4-6 hours as needed
- Fever reduction: 200-400mg every 4-6 hours as needed
- Inflammatory conditions: 400-800mg every 6-8 hours
- Maximum daily dose: 3200mg
Pediatric Dosing
- Children 6 months to 12 years: 5-10mg/kg every 6-8 hours
- Juvenile arthritis: 20-40mg/kg/day in divided doses
- Fever reduction: 5-10mg/kg every 6-8 hours
Indications
- Relief of mild to moderate pain
- Treatment of inflammatory conditions such as rheumatoid arthritis, osteoarthritis
- Reduction of fever
- Management of primary dysmenorrhea
Mechanism of Action
- Inhibition of prostaglandin synthesis by blocking COX-1 and COX-2 enzymes
- Interference with the body's production of prostaglandins, reducing inflammation and pain
Contraindications
- Hypersensitivity to ibuprofen or other NSAIDs
- Active peptic ulcer disease
- History of asthma, urticaria, or allergic reactions to NSAIDs
- Severe renal impairment or heart failure
Adverse Reactions
- Gastrointestinal upset, nausea, vomiting, diarrhea
- Headache, dizziness, drowsiness
- Allergic reactions such as rash, itching, swelling
- Increased risk of cardiovascular events, renal impairment
Drug Interactions
- Increased risk of bleeding with anticoagulants, antiplatelets
- Reduced antihypertensive effect with diuretics, beta-blockers
- Increased nephrotoxicity with other nephrotoxic agents
- Altered lithium levels, increased toxicity
Curated Content: Needs Vetting Before Put to Clinical Use