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MUSCULO-SKELETAL SYSTEM › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN › Capsaicin and similar agents
capsaicin
M02AB01
Forms & Strengths
- Cream (0.025%, 0.075%)
- Patch (8% capsaicin)
- Gel
- Liquid (0.025%)
- Lotion
Adult Dosing
- Topical cream: apply 3-4 times daily
- Transdermal patch: apply for 30 minutes to 1 hour, no more than 4 times in a 24-hour period
- Start with low concentration, titrate up
Pediatric Dosing
- Safety and efficacy not established in children under 18 years
- Use with caution in children 2-18 years old with certain conditions
Indications
- Relief of minor aches and pains of muscles and joints
- Postherpetic neuralgia
- Diabetic neuropathy
- Osteoarthritis
Mechanism of Action
- Activates sensory neurons and induces the release of substance P
- Depletes substance P from sensory neurons
- Blocks the production and transport of pain-producing chemicals
Contraindications
- Hypersensitivity to capsaicin or any component
- Open wounds, denuded skin
Adverse Reactions
- Burning sensation
- Erythema
- Paresthesia
- Pruritus
- Transient increase in blood pressure
Drug Interactions
- May reduce the efficacy of certain medications (e.g., ACE inhibitors)
- Concomitant use with medications that alter blood pressure (e.g., beta blockers) requires caution
Curated Content: Needs Vetting Before Put to Clinical Use