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MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS › Curare alkaloids
tubocurarine
M03AA02
Forms & Strengths
- Injection: 3 mg/mL, 5 mg/mL, 10 mg/mL, 15 mg/mL
- Powder for injection: 5 mg, 10 mg, 15 mg
Adult Dosing
- Initial dose: 0.1-0.2 mg/kg IV
- Maintenance dose: 0.01-0.1 mg/kg IV
- Maximum dose: 0.5 mg/kg
Pediatric Dosing
- Neonates: 0.1-0.2 mg/kg IV
- Infants and children: 0.1-0.5 mg/kg IV
- Titrate dose to effect
Indications
- Facilitation of tracheal intubation
- Skeletal muscle relaxation during surgery or mechanical ventilation
- Treatment of tetanus
Mechanism of Action
- Competitive antagonist of acetylcholine at the nicotinic receptor
- Blocks neuromuscular transmission
- Inhibits skeletal muscle contraction
Contraindications
- Hypersensitivity to tubocurarine or other neuromuscular blockers
- Myasthenia gravis
- Eaton-Lambert syndrome
Adverse Reactions
- Respiratory depression or paralysis
- Anaphylaxis or hypersensitivity reactions
- Hypotension
- Cardiac arrhythmias
- Increased intraocular pressure
Drug Interactions
- Aminoglycoside antibiotics: potentiation of neuromuscular blockade
- Succinylcholine: increased risk of prolonged apnea
- Inhalational anesthetics: enhanced neuromuscular blockade
- Anticholinesterase inhibitors: reversal of neuromuscular blockade
Curated Content: Needs Vetting Before Put to Clinical Use