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MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS › Other quaternary ammonium compounds
gallamine
M03AC02
Forms & Strengths
- Injection: 40mg/mL
- Powder for injection: 40mg/vial
Adult Dosing
- Initial dose: 40-100mg IV
- Maintenance dose: 20-40mg IV as needed
- Intubation dose: 80-100mg IV
Pediatric Dosing
- Neonates and infants: 0.5-1mg/kg/dose IV
- Children 1-12 years: 1-2mg/kg/dose IV
- Maximum pediatric dose: 40mg
Indications
- Skeletal muscle relaxation during surgery or mechanical ventilation
- Adjunct to anesthesia
- Emergency intubation
Mechanism of Action
- Competitive antagonist of nicotinic acetylcholine receptors at the neuromuscular junction
- Blocks acetylcholine from binding to receptors, preventing muscle contraction
Contraindications
- Known hypersensitivity to gallamine
- Myasthenia gravis
- Eaton-Lambert syndrome
- Severe respiratory disease
Adverse Reactions
- Residual muscle weakness
- Anaphylaxis
- Tachycardia
- Hypertension
- Bronchospasm
Drug Interactions
- Enhanced neuromuscular blockade with other anesthetics and neuromuscular blockers
- Increased heart rate with anticholinergics
- Reduced effect with acetylcholinesterase inhibitors
Curated Content: Needs Vetting Before Put to Clinical Use