← Search & browse all drugs
MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS › Other quaternary ammonium compounds
fazadinium bromide
M03AC08
Forms & Strengths
- Injection: 10mg/mL
- Powder for injection: 20mg/vial
Adult Dosing
- Initial dose: 0.1mg/kg IV over 2 minutes
- Maintenance dose: 0.05-0.1mg/kg IV as needed
Pediatric Dosing
- Safety and efficacy not established
- Use with caution in pediatric patients
Indications
- Non-depolarizing neuromuscular blockade
- Facilitating tracheal intubation
- Skeletal muscle relaxation during surgery
Mechanism of Action
- Competitively inhibiting acetylcholine at nicotinic receptors
- Blocking neuromuscular transmission
Contraindications
- Known hypersensitivity to fazadinium bromide
- Myasthenia gravis
- Eaton-Lambert syndrome
Adverse Reactions
- Anaphylaxis
- Hypotension
- Bradycardia
- Residual neuromuscular blockade
Drug Interactions
- Anesthetics: potentiate neuromuscular blockade
- Aminoglycosides: potentiate neuromuscular blockade
- Anticholinesterases: may reverse neuromuscular blockade
Curated Content: Needs Vetting Before Put to Clinical Use