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MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS › Other quaternary ammonium compounds
mivacurium chloride
M03AC10
Forms & Strengths
- Injection: 2 mg/mL
- Lyophilized powder for injection: 10 mg, 20 mg
Adult Dosing
- Initial dose: 0.15-0.25 mg/kg IV
- Maintenance dose: 0.01-0.03 mg/kg IV, repeated as needed
Pediatric Dosing
- Neonates and infants: 0.2 mg/kg IV
- Children: 0.15-0.25 mg/kg IV
Indications
- Facilitation of tracheal intubation
- Skeletal muscle relaxation during surgery or mechanical ventilation
Mechanism of Action
- Non-depolarizing neuromuscular blocking agent
- Competitively inhibits nicotinic acetylcholine receptors at the neuromuscular junction
Contraindications
- Known hypersensitivity to mivacurium or other neuromuscular blocking agents
- Patients with myasthenia gravis or other neuromuscular disorders
Adverse Reactions
- Bronchospasm
- Hypotension
- Flushing
- Histamine release
- Anaphylaxis
Drug Interactions
- Inhalational anesthetics: potentiate neuromuscular blockade
- Aminoglycosides: potentiate neuromuscular blockade
- Magnesium salts: potentiate neuromuscular blockade
Curated Content: Needs Vetting Before Put to Clinical Use