← Search & browse all drugs
MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS › Carbamic acid esters
methocarbamol
M03BA03
Forms & Strengths
- Tablets: 500mg, 750mg
- Injectable: 100mg/mL
Adult Dosing
- Musculoskeletal pain: 1.5g qid, max 8g/day
- Tetanus: 1.5g qid, max 24g/day
- Surgery: 1g 2-3 hours preop
Pediatric Dosing
- Safety and efficacy not established
- Use with caution in children under 16
Indications
- Relief of acute inflammatory and traumatic musculoskeletal conditions
- Adjunct therapy in tetanus
Mechanism of Action
- Centrally acting muscle relaxant
- Inhibits nerve transmission in the spinal cord
- Does not act at the neuromuscular junction
Contraindications
- Known hypersensitivity to methocarbamol
- Myasthenia gravis
Adverse Reactions
- Drowsiness
- Dizziness
- Abdominal cramps
- Nausea and vomiting
Drug Interactions
- CNS depressants: additive sedative effects
- Anticholinesterase agents: decreased efficacy
- Pyridostigmine: potentiation of side effects
Curated Content: Needs Vetting Before Put to Clinical Use