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MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS › Carbamic acid esters
phenprobamate, combinations excl. psycholeptics
M03BA51
Forms & Strengths
- 200mg tablets
- 400mg tablets
- oral suspension
Adult Dosing
- Initial dose: 2.4g daily, divided into 3 doses
- Maintenance dose: 1.2-1.8g daily, divided into 3 doses
- Not recommended for long-term use
Pediatric Dosing
- Not recommended for children under 12 years old
- For children 12 years and older, use adult dosing with caution
- Dosage should be individualized and adjusted according to response
Indications
- Muscle spasms
- Tension headaches
- Restless leg syndrome
- Parkinsonian tremors
Mechanism of Action
- Centrally acting muscle relaxant
- Acts on the brain to produce a sedative effect
- Blocks nerve impulses that cause muscle contractions
Contraindications
- Hypersensitivity to phenprobamate or related compounds
- Porphyria
- Acute intermittent porphyria
Adverse Reactions
- Drowsiness
- Dizziness
- Headache
- Nausea and vomiting
- Dry mouth
- Constipation
Drug Interactions
- Enhanced sedation with other CNS depressants
- Concomitant use with antihistamines or scopolamine may increase sedative effects
- Interacts with MAO inhibitors to increase the risk of hypertensive crises
Curated Content: Needs Vetting Before Put to Clinical Use