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methocarbamol, combinations excl. psycholeptics

M03BA53

Forms & Strengths

Oral Tablet: 500 mg
Oral Tablet: 750 mg
Injectable Solution: 100 mg/mL in 10 mL vials

Adult Dosing

Oral: 1.5 g q.i.d. for the first 48 to 72 hours, then maintenance of 4 g/day divided in 3 to 4 doses
Intravenous/Intramuscular: 1 g to 3 g administered as a single dose, not exceeding 3 g/day for more than 3 consecutive days except in tetanus

Pediatric Dosing

Safety and efficacy in pediatric patients below 16 years of age have not been established except in tetanus
Tetanus (Off-label): 15 mg/kg to 40 mg/kg IV every 4 hours or continuous infusion up to 1800 mg/m2/day

Indications

Adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions

Mechanism of Action

Central nervous system depressant acting primarily at the level of the spinal cord and subcortical areas to produce skeletal muscle relaxation by general sedation

Contraindications

Hypersensitivity to methocarbamol or any component of the formulation
Renal impairment (for injectable form due to polyethylene glycol vehicle)

Adverse Reactions

Dizziness
Drowsiness
Lightheadedness
Nausea
Pruritus
Urticaria
Fever
Anaphylactic reaction
Nystagmus
Blurred vision

Drug Interactions

Potentiation of central nervous system depressants including alcohol, barbiturates, narcotics, and appetite suppressants
May potentiate the effects of anticholinergic drugs
Can interfere with 5-HIAA urinary excretion screening tests causing false-positive results

Curated Content: Needs Vetting Before Put to Clinical Use