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carisoprodol, combinations with psycholeptics

M03BA72

Forms & Strengths

Carisoprodol 250 mg / Aspirin 325 mg tablet
Carisoprodol 200 mg / Aspirin 325 mg / Codeine phosphate 16 mg tablet
Carisoprodol combinations often include psycholeptics like meprobamate or barbiturates for enhanced sedation

Adult Dosing

1 tablet orally 3 times daily and at bedtime
Limit use to short-term (up to 2-3 weeks) due to potential for abuse and dependence

Pediatric Dosing

Safety and efficacy not established in pediatric patients under 16 or 18 years of age depending on specific combination product

Indications

Adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions

Mechanism of Action

Central nervous system depression resulting in skeletal muscle relaxation
Carisoprodol is metabolized to meprobamate, which has anxiolytic and sedative properties
Combined with psycholeptics, produces synergistic central nervous system depression

Contraindications

Acute intermittent porphyria
Known hypersensitivity to carisoprodol, meprobamate, aspirin, or codeine components
History of drug abuse or acute severe respiratory depression

Adverse Reactions

Drowsiness, dizziness, vertigo, and ataxia
Tachycardia, orthostatic hypotension, and flushing
Nausea, vomiting, and epigastric distress
Risk of dependence, withdrawal syndrome, and CNS depression

Drug Interactions

Central nervous system depressants (alcohol, opioids, psycholeptics) cause additive impairment
CYP2C19 inhibitors (e.g., omeprazole, fluvoxamine) may increase carisoprodol concentrations
CYP2C19 inducers (e.g., rifampin, St. John's wort) may decrease carisoprodol efficacy
Anticoagulants and NSAIDs combined with aspirin components increase bleeding risk

Curated Content: Needs Vetting Before Put to Clinical Use