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MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS › Other centrally acting agents
tolperisone
M03BX04
Forms & Strengths
- Tablets: 50mg, 100mg, 150mg, 200mg
- Injection: 50mg/mL, 100mg/mL
Adult Dosing
- Muscle spasms: 50-100mg tid
- Muscle spasticity: 100-150mg tid
- Maximum daily dose: 450mg
Pediatric Dosing
- Not established for children under 12 years
- 12-18 years: 25-50mg tid
- Dosing should be individualized and monitored closely
Indications
- Symptomatic treatment of muscle spasms and spasticity
- Relief of musculoskeletal pain and discomfort
- Treatment of cerebral spasticity and spinal cord injuries
Mechanism of Action
- Centrally acting muscle relaxant
- Acts as a selective blockade of voltage-gated sodium channels
- Inhibits the release of acetylcholine and other neurotransmitters
Contraindications
- Hypersensitivity to tolperisone or its components
- Pregnancy and lactation: use only when benefits outweigh risks
- Severe liver or kidney impairment
Adverse Reactions
- Drowsiness, dizziness, and headache
- Nausea, vomiting, and gastrointestinal upset
- Rares: allergic reactions, anaphylaxis, and seizures
Drug Interactions
- Increased sedation with CNS depressants and sedatives
- Potentiation of neuromuscular blockade with anesthetics
- Reduced efficacy with certain anticonvulsants and analgesics
Curated Content: Needs Vetting Before Put to Clinical Use