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MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS › Other centrally acting agents
thiocolchicoside
M03BX05
Forms & Strengths
- Oral capsules: 4 mg, 8 mg
- Intramuscular solution: 4 mg/2 mL
- Topical cream/ointment: 0.25%
Adult Dosing
- Oral: 8 mg every 12 hours (maximum 7 consecutive days)
- Intramuscular: 4 mg twice daily (maximum 5 consecutive days)
- Topical: Apply 2-3 times daily to affected area
Pediatric Dosing
- Safety and efficacy not established in patients under 18 years of age
Indications
- Adjunctive treatment of painful muscle spasms in acute spinal pathology
- Rheumatological and neurological disorders associated with spasticity
Mechanism of Action
- Acts as a competitive GABA-A receptor antagonist and glycine receptor antagonist
- Exerts muscle relaxant effects centrally via spinal pathways
Contraindications
- Known hypersensitivity to thiocolchicoside or colchicine
- Flaccid paralysis or hypotonia
- Pregnancy and lactation
- Women of childbearing potential not using effective contraception
Adverse Reactions
- Somnolence, drowsiness
- Gastralgia, nausea, vomiting, diarrhea
- Hypersensitivity reactions including urticaria, pruritus, angioedema
- Seizures in patients with pre-existing epilepsy
Drug Interactions
- Metabolite (SL18.0970) may induce genetic damage at high systemic concentrations, raising theoretical interaction concerns with other genotoxic agents
- Concomitant central nervous system depressants may potentiate sedation
Curated Content: Needs Vetting Before Put to Clinical Use