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MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS › Other centrally acting agents
eperisone
M03BX09
Forms & Strengths
- Tablets: 50mg, 100mg
- Oral solution: 50mg/5mL
Adult Dosing
- Initial dose: 50mg TID
- Maintenance dose: 100mg TID
- Maximum dose: 300mg/day
Pediatric Dosing
- Not recommended for children under 12 years
- Dosing for children over 12 years: 50mg TID, titrate to effect
Indications
- Treatment of musculoskeletal disorders
- Relief of muscle spasm
- Adjunctive therapy for low back pain
Mechanism of Action
- Acts as a calcium channel blocker
- Inhibits calcium influx into muscle cells
- Produces muscle relaxation
Contraindications
- Hypersensitivity to eperisone
- Pregnancy, especially in the first trimester
- Severe liver or kidney dysfunction
Adverse Reactions
- Dizziness
- Somnolence
- Nausea
- Headache
- Abdominal pain
Drug Interactions
- Enhanced sedation with CNS depressants
- Increased risk of hypotension with antihypertensives
- Interference with effects of levodopa
Curated Content: Needs Vetting Before Put to Clinical Use