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MUSCULO-SKELETAL SYSTEM › MUSCLE RELAXANTS › MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS › Other centrally acting agents
thiocolchicoside, combinations
M03BX55
Forms & Strengths
- Tablets: 4mg, 8mg
- Capsules: 4mg
- Injectable solution: 2mg/ml, 4mg/2ml
Adult Dosing
- Muscle spasms: 8mg tid
- Acute lower back pain: 8mg bid
- Chronic lower back pain: 4mg tid
Pediatric Dosing
- Not recommended for children under 12 years
- 12-18 years: 4mg tid for muscle spasms and acute lower back pain
Indications
- Relief of muscle spasms of various origins
- Symptomatic treatment of low back pain
- Treatment of osteoarticular and extra-articular rheumatism
Mechanism of Action
- Acts as a semi-synthetic derivative of colchicine with muscle relaxant properties
- Exerts antispastic and anti-inflammatory effects
Contraindications
- Hypersensitivity to thiocolchicoside or colchicine
- Severe gastrointestinal disorders
- Breastfeeding
Adverse Reactions
- Gastrointestinal disturbances
- Dizziness and drowsiness
- Allergic reactions
Drug Interactions
- May enhance the sedative effect of CNS depressants
- Increased risk of gastrointestinal bleeding with NSAIDs
- May decrease the efficacy of oral contraceptives
Curated Content: Needs Vetting Before Put to Clinical Use