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MUSCULO-SKELETAL SYSTEM › ANTIGOUT PREPARATIONS › ANTIGOUT PREPARATIONS › Preparations inhibiting uric acid production
tisopurine
M04AA02
Forms & Strengths
- Tablets: 50mg, 100mg, 200mg
- Oral solution: 50mg/5mL
Adult Dosing
- Gout: 50-100mg orally once daily
- Chronic hyperuricemia: 100-200mg orally twice daily
- Max dose: 400mg/day
Pediatric Dosing
- Safety and efficacy not established in children
- Not recommended for use in pediatric patients
Indications
- Gout
- Chronic hyperuricemia
- Prevention of uric acid nephropathy
Mechanism of Action
- Xanthine oxidase inhibitor
- Decreases uric acid production
- Increases uric acid excretion
Contraindications
- Hypersensitivity to tisopurine
- Pregnancy and lactation
- Severe hepatic or renal impairment
Adverse Reactions
- Gastrointestinal disturbances
- Headache
- Skin rash
- Hepatotoxicity
- Myelosuppression
Drug Interactions
- Allopurinol: increased risk of hypersensitivity reactions
- Xanthines: decreased efficacy
- Azathioprine: increased risk of myelosuppression
- Theophylline: decreased clearance
Curated Content: Needs Vetting Before Put to Clinical Use