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aluminium chlorohydrate

M05BX02

Forms & Strengths

Topical solution 20%
Topical aerosol 10-20%
Topical roll-on/gel 15-25%

Adult Dosing

Apply thinly to clean, dry axillae once daily, preferably at bedtime
Wash off thoroughly in the morning
Frequency may be reduced to twice weekly once hyperhidrosis is controlled

Pediatric Dosing

Safety and efficacy not established in children under 12 years
Use in adolescents 12-17 years same as adult dosing under supervision

Indications

Primary axillary hyperhidrosis
Antiperspirant for excessive sweating

Mechanism of Action

Precipitates proteins in the sweat ducts to form a physical gel block
Temporarily occludes the lumens of the eccrine sweat glands
Reduces the flow of sweat to the skin surface

Contraindications

Hypersensitivity to aluminum compounds
Application to broken, irritated, or freshly shaved skin
Use on mucous membranes

Adverse Reactions

Local skin irritation and stinging
Erythema and pruritus at application site
Contact dermatitis with prolonged use
Staining of clothing

Drug Interactions

None significant via topical route due to minimal systemic absorption
May increase local irritation when used concomitantly with other topical keratolytics or retinoids

Curated Content: Needs Vetting Before Put to Clinical Use