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MUSCULO-SKELETAL SYSTEM › OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM › OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM › Quinine and derivatives
hydroquinine
M09AA01
Forms & Strengths
- Tablets: 200mg, 300mg
- Injectable: 300mg/mL
Adult Dosing
- Malaria treatment: 300mg every 6 hours for 3-5 days
- Malaria prophylaxis: 300mg once weekly
Pediatric Dosing
- 5-12 years: 5mg/kg every 6 hours for 3-5 days, max 300mg/dose
- Under 5 years: Not recommended due to safety concerns
Indications
- Treatment and prevention of malaria
- Chloroquine-resistant malaria
Mechanism of Action
- Interferes with heme detoxification pathway in Plasmodium parasites
- Inhibits nucleic acid synthesis in parasites
Contraindications
- Hypersensitivity to hydroquinine or 4-aminoquinolines
- Glucose-6-phosphate dehydrogenase deficiency
Adverse Reactions
- Hematologic: anemia, agranulocytosis
- Gastrointestinal: nausea, vomiting, diarrhea
- Dermatologic: pruritus, skin rash
Drug Interactions
- Antacids: Reduce hydroquinine absorption
- Cimetidine: Increases hydroquinine levels
Curated Content: Needs Vetting Before Put to Clinical Use