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trypsin, combinations

M09AB52

Forms & Strengths

Oral tablets/capsules containing trypsin combined with other proteolytic enzymes (e.g., chymotrypsin, papain, bromelain, rutoside)

Adult Dosing

1 to 2 tablets orally 3 to 4 times daily, typically taken between meals with water, depending on the specific combination product and clinical indication

Pediatric Dosing

Safety and efficacy not established in pediatric patients; use is generally not recommended

Indications

Adjunctive treatment of edema, inflammation, and soft tissue trauma resulting from surgery, injury, or inflammatory conditions

Mechanism of Action

Proteolytic enzymes hydrolyze proteins and peptides involved in the inflammatory cascade, reducing capillary permeability, decreasing edema, and facilitating the removal of inflammatory exudates

Contraindications

Hypersensitivity to trypsin or any component of the combination product
Severe congenital or acquired blood coagulation disorders (e.g., hemophilia)
Severe hepatic or renal impairment
Patients receiving concurrent anticoagulant therapy

Adverse Reactions

Gastrointestinal upset (nausea, diarrhea, dyspepsia)
Allergic reactions (rash, pruritus, urticaria)
Increased risk of bleeding or hematoma formation due to fibrinolytic activity

Drug Interactions

Anticoagulants and antiplatelet agents (increased risk of bleeding)
Certain antibiotics (e.g., tetracyclines, amoxicillin), as proteolytic enzymes may alter their absorption or tissue penetration

Curated Content: Needs Vetting Before Put to Clinical Use