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NERVOUS SYSTEM › ANESTHETICS › ANESTHETICS, GENERAL › Barbiturates in combination with other drugs
narcobarbital
N01AG01
Forms & Strengths
- Tablets: 15mg, 30mg, 50mg, 100mg
- Oral solution: 4mg/ml
Adult Dosing
- Sedation: 15-30mg orally 2-3 times a day
- Insomnia: 50-100mg orally at bedtime
- Seizures: 200-400mg orally 2-3 times a day
Pediatric Dosing
- Sedation: 2-6mg/kg orally 2-3 times a day
- Insomnia: 3-6mg/kg orally at bedtime
Indications
- Sedation
- Insomnia
- Seizures
- Pre-anesthetic medication
Mechanism of Action
- Potentiation of GABA activity
- Enhancement of chloride influx into neurons
- Decreased neuronal excitability
Contraindications
- Porchiria
- Severe respiratory depression
- Acute or severe asthma
- Hypersensitivity to barbiturates
Adverse Reactions
- Respiratory depression
- Sedation
- Drowsiness
- Ataxia
- Confusion
- Hypotension
Drug Interactions
- CNS depressants: additive sedative effects
- Opioids: increased risk of respiratory depression
- MAOIs: increased risk of hypotension
Curated Content: Needs Vetting Before Put to Clinical Use