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NERVOUS SYSTEM › ANESTHETICS › ANESTHETICS, GENERAL › Opioid anesthetics
phenoperidine
N01AH04
Forms & Strengths
- Injection: 2mg/mL, 5mg/mL, 10mg/mL
- Tablets: 5mg, 10mg
Adult Dosing
- Analgesia: 1-2mg IM/IV, may repeat every 3-4 hours as needed
- Pre-anesthetic medication: 1-2mg IM/IV, 30-60 minutes before surgery
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Use with caution in children, dose adjustment may be necessary
Indications
- Moderate to severe pain
- Pre-anesthetic medication for surgery or medical procedures
Mechanism of Action
- Selective mu-opioid receptor agonist
- Inhibits pain transmission by interacting with opioid receptors in CNS
Contraindications
- Hypersensitivity to phenoperidine or other opioids
- Respiratory depression, severe asthma, or chronic obstructive pulmonary disease
- Increased intracranial pressure, head trauma, or brain tumor
Adverse Reactions
- Respiratory depression, apnea
- Sedation, drowsiness, confusion
- Nausea, vomiting, constipation
- Pruritus, urticaria, anaphylaxis (rare)
Drug Interactions
- CNS depressants (e.g., benzodiazepines, barbiturates): additive sedative effects
- Monoamine oxidase inhibitors (MAOIs): increased risk of serotonin syndrome
- Anticholinergics (e.g., atropine): increased risk of urinary retention, constipation
Curated Content: Needs Vetting Before Put to Clinical Use