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NERVOUS SYSTEM › ANESTHETICS › ANESTHETICS, GENERAL › Other general anesthetics
sodium oxybate
N01AX11
Adult Dosing
- Narcolepsy with cataplexy or excessive daytime sleepiness: Initial 4.5 g/night orally in two divided doses (2.25 g each); titrate by 1.5 g/night at 1-to-2-week intervals to max 9 g/night.
- Idiopathic hypersomnia: Initial 4.5 g/night orally in two divided doses; titrate by 1.5 g/night at 1-to-2-week intervals to max 9 g/night.
Pediatric Dosing
- Pediatric patients 7 years and older with narcolepsy: Weight-based or fixed low starting doses, titrated up to maximum 9 g/night divided into two nightly doses.
Indications
- Treatment of cataplexy or excessive daytime sleepiness in patients with narcolepsy
- Treatment of idiopathic hypersomnia in adults
Mechanism of Action
- CNS depressant and gamma-aminobutyric acid (GABA-B) receptor agonist.
- Enhances slow-wave sleep and consolidates sleep architecture.
Contraindications
- Succinic semialdehyde dehydrogenase deficiency
- Concomitant use with sedative-hypnotics or alcohol
- Concomitant use with other CNS depressants
Adverse Reactions
- Dizziness
- Nausea
- Enuresis
- Headache
- Nasopharyngitis
- Somnolence
- Vomiting
- Depression
- Confusion
- Sleepwalking
Drug Interactions
- Alcohol: Severe potentiation of CNS depression and respiratory depression.
- CNS depressants (opioids, benzodiazapines, sedatives): Increased risk of respiratory depression, hypotension, profound sedation, or coma.
- Valproate: Increases systemic exposure of sodium oxybate, requiring potential dose reduction.
Curated Content: Needs Vetting Before Put to Clinical Use