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metabutethamine

N01BA01

Forms & Strengths

Injection: 1:1000 (1 mg/mL)

Adult Dosing

Typical dose: 5-20 mg IV, may repeat as needed

Pediatric Dosing

Not well established

Indications

Local anesthesia
Diagnostic procedures

Mechanism of Action

Blocks sodium channels on nerve fibers, preventing depolarization

Contraindications

Hypersensitivity to metabutethamine or amide local anesthetics
Infection or inflammation at injection site

Adverse Reactions

Local pain or inflammation
Allergic reactions
CNS toxicity (high doses)
Cardiovascular effects (high doses)

Drug Interactions

Sulfonamides may enhance toxicity
MAOIs may increase risk of serotonin syndrome

Curated Content: Needs Vetting Before Put to Clinical Use